SASS can handle vendor prefixes efficiently using the `autoprefixer` tool or mixins. For example, you can use `@mixin` to create a mixin for vendor prefixes:`@mixin border-radius($radius) { -webkit-border-radius: $radius; -moz-border-radius: $radius; border-radius: $radius; }` and then include it where needed. Alternatively,`autoprefixer` can automatically add prefixes based on browser compatibility.